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David C Markel Selected Research

Erythromycin (Erycette)

10/2016The Chondroprotective Role of Erythromycin in a Murine Joint Destruction Model.
8/2014Effect of erythromycin-doped calcium polyphosphate scaffold composite in a mouse pouch infection model.
8/2011Emerging ideas: can erythromycin reduce the risk of aseptic loosening?
1/2011Cyclodextrin-erythromycin complexes as a drug delivery device for orthopedic application.
12/2010Efficacy of periprosthetic erythromycin delivery for wear debris-induced inflammation and osteolysis.
7/2009Inhibitory effects of erythromycin on wear debris-induced VEGF/Flt-1 gene production and osteolysis.

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David C Markel Research Topics

Disease

14Inflammation (Inflammations)
10/2016 - 05/2005
9Infections
10/2022 - 09/2013
7Osteolysis
08/2011 - 10/2006
2Wounds and Injuries (Trauma)
01/2017 - 01/2010
2Hemorrhage
01/2010 - 09/2007
2Bone Resorption
07/2009 - 01/2007
1Pain (Aches)
01/2022
1Staphylococcal Infections
07/2017
1Hypertrophy
01/2017
1Synovitis
10/2016
1Arthralgia (Joint Pain)
10/2016
1Stroke (Strokes)
01/2016
1Myocardial Infarction
01/2016
1Osteomyelitis
12/2015
1Venous Thromboembolism
01/2012
1Communicable Diseases (Infectious Diseases)
01/2011
1Sarcoma (Soft Tissue Sarcoma)
08/2008
1Knee Osteoarthritis
01/2007
1Venous Thrombosis (Deep-Vein Thrombosis)
01/2002

Drug/Important Bio-Agent (IBA)

8ultra-high molecular weight polyethylene (UHMWPE)IBA
08/2014 - 10/2006
6Erythromycin (Erycette)FDA LinkGeneric
10/2016 - 07/2009
4Anti-Bacterial Agents (Antibiotics)IBA
10/2022 - 01/2011
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2011 - 10/2006
3Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
01/2011 - 10/2006
2CytokinesIBA
07/2019 - 08/2014
2TitaniumIBA
07/2017 - 08/2011
2Interleukin-1 (Interleukin 1)IBA
01/2012 - 07/2009
2Polyethylene (Polythene)IBA
08/2011 - 08/2008
2Proteins (Proteins, Gene)FDA Link
01/2011 - 07/2009
2Interleukin-1beta (Interleukin 1 beta)IBA
06/2008 - 01/2007
2CollagenIBA
06/2008 - 01/2007
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2008 - 01/2007
1Opioid Analgesics (Opioids)IBA
01/2022
1Polyvinyl AlcoholIBA
01/2022
1Tobramycin (Nebcin)FDA LinkGeneric
01/2022
1VancomycinFDA LinkGeneric
01/2022
1C-Reactive ProteinIBA
07/2019
1Hemoglobins (Hemoglobin)IBA
11/2017
1Doxycycline (Periostat)FDA LinkGeneric
07/2017
1Iodoacetic AcidIBA
10/2016
1Opiate AlkaloidsIBA
10/2016
1Polymethyl Methacrylate (Sol)IBA
12/2015
1Bone SubstitutesIBA
12/2015
1hylanIBA
10/2014
1Chemokine ReceptorsIBA
08/2014
1ChemokinesIBA
08/2014
1PolyphosphatesIBA
08/2014
1CalciumIBA
08/2014
1poly(vinyl alcohol)-hylauronic acidIBA
09/2013
1Messenger RNA (mRNA)IBA
01/2012
1Durapatite (Hydroxylapatite)IBA
08/2011
1ApatitesIBA
08/2011
1CyclodextrinsIBA
01/2011
1Semaxinib (SU5416)IBA
01/2011
1Neutralizing AntibodiesIBA
01/2011
1Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA
01/2010
1Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
01/2010
1Liposomes (Liposome)IBA
06/2008
1Clodronic Acid (Clodronate)IBA
06/2008
1Warfarin (Coumadin)FDA LinkGeneric
09/2007
1AnticoagulantsIBA
09/2007
1Anesthetics (Anesthetic Agents)IBA
09/2007
1Saline SolutionIBA
01/2007
1Hyaluronic Acid (Hyaluronan)IBA
01/2007
1Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
05/2005

Therapy/Procedure

4Arthroplasty
01/2022 - 09/2007
3Prostheses and Implants (Prosthesis)
10/2022 - 05/2005
3Sutures (Suture)
12/2020 - 01/2017
2Length of Stay
11/2017 - 01/2016
2Replacement Arthroplasty
09/2013 - 01/2002
1Home Nursing (Nursing, Home)
11/2017
1Injections
10/2014
1Reoperation
08/2011
1Therapeutics
08/2008
1Epidural Anesthesia
09/2007
1Catheters
09/2007
1Intra-Articular Injections
01/2007